GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

When SUCNR1/GPR91-expressing macrophages are activated by inflammatory signals, they change their metabolism and accumulate succinate. In this study, we show that during this activation, macrophages release succinate into the extracellular milieu. They simultaneously up-regulate GPR91, which functio...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Littlewood-Evans, Amanda, Sarret, Sophie, Apfel, Verena, Loesle, Perrine, Dawson, Janet, Zhang, Juan, Muller, Alban, Tigani, Bruno, Kneuer, Rainer, Patel, Saijel, Valeaux, Stephanie, Gommermann, Nina, Rubic-Schneider, Tina, Junt, Tobias, Carballido, José M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995082/
https://ncbi.nlm.nih.gov/pubmed/27481132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160061
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