Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury

BACKGROUND: Administration of granulocyte-macrophage colony stimulating factor (GM-CSF) relieves symptoms in Crohn's disease (CD). It has been reported that reduced GM-CSF bioactivity is associated with more aggressive ileal behaviour and that GM-CSF-null mice exhibit ileal barrier dysfunction...

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Bibliographische Detailangaben
Veröffentlicht in:Gut
Hauptverfasser: Han, Xiaonan, Gilbert, Shila, Groschwitz, Katherine, Hogan, Simon, Jurickova, Ingrid, Trapnell, Bruce, Samson, Charles, Gully, Jonathan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296557/
https://ncbi.nlm.nih.gov/pubmed/20584783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2009.203893
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