Paediatric Crohn disease patients with stricturing behaviour exhibit ileal granulocyte–macrophage colony-stimulating factor (GM-CSF) autoantibody production and reduced neutrophil bacterial killing and GM-CSF bioactivity

Granulocyte–macrophage colony-stimulating factor (GM-CSF) autoantibodies are associated with stricturing behaviour in Crohn disease (CD). We hypothesized that CD ileal lamina propria mononuclear cells (LPMC) would produce GM-CSF autoantibodies and peripheral blood (PB) samples would contain GM-CSF n...

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Detalhes bibliográficos
Main Authors: Jurickova, I, Collins, M H, Chalk, C, Seese, A, Bezold, R, Lake, K, Allmen, D, Frischer, J S, Falcone, R A, Trapnell, B C, Denson, L A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646445/
https://ncbi.nlm.nih.gov/pubmed/23600834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12076
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