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Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia
Megakaryocyte ploidy and the generation of pre/proplatelets are both increased in culture by pharmacologic inhibition of myosin-II, but nonmuscle myosin-IIA (MIIA) mutations paradoxically cause MYH9-related diseases (MYH9-RD) that adversely affect platelets. In marrow, megakaryocytes extend projecti...
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| Udgivet i: | Blood |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4296012/ https://ncbi.nlm.nih.gov/pubmed/25395423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-576462 |
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