Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia

Megakaryocyte ploidy and the generation of pre/proplatelets are both increased in culture by pharmacologic inhibition of myosin-II, but nonmuscle myosin-IIA (MIIA) mutations paradoxically cause MYH9-related diseases (MYH9-RD) that adversely affect platelets. In marrow, megakaryocytes extend projecti...

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Bibliografische gegevens
Gepubliceerd in:Blood
Hoofdauteurs: Spinler, Kyle R., Shin, Jae-Won, Lambert, Michele P., Discher, Dennis E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2015
Onderwerpen:
Platelets and Thrombopoiesis
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296012/
https://ncbi.nlm.nih.gov/pubmed/25395423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-576462
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