Ranolazine inhibits Na(V)1.5-mediated breast cancer cell invasiveness and lung colonization

BACKGROUND: Na(V)1.5 voltage-gated sodium channels are abnormally expressed in breast tumours and their expression level is associated with metastatic occurrence and patients’ death. In breast cancer cells, Na(V)1.5 activity promotes the proteolytic degradation of the extracellular matrix and enhanc...

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Опубликовано в: :Mol Cancer
Главные авторы: Driffort, Virginie, Gillet, Ludovic, Bon, Emeline, Marionneau-Lambot, Séverine, Oullier, Thibauld, Joulin, Virginie, Collin, Christine, Pagès, Jean-Christophe, Jourdan, Marie-Lise, Chevalier, Stéphan, Bougnoux, Philippe, Le Guennec, Jean-Yves, Besson, Pierre, Roger, Sébastien
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2014
Предметы:
Short Communication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295566/
https://ncbi.nlm.nih.gov/pubmed/25496128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-264
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