Ranolazine inhibits Na(V)1.5-mediated breast cancer cell invasiveness and lung colonization

BACKGROUND: Na(V)1.5 voltage-gated sodium channels are abnormally expressed in breast tumours and their expression level is associated with metastatic occurrence and patients’ death. In breast cancer cells, Na(V)1.5 activity promotes the proteolytic degradation of the extracellular matrix and enhanc...

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Veröffentlicht in:Mol Cancer
Hauptverfasser: Driffort, Virginie, Gillet, Ludovic, Bon, Emeline, Marionneau-Lambot, Séverine, Oullier, Thibauld, Joulin, Virginie, Collin, Christine, Pagès, Jean-Christophe, Jourdan, Marie-Lise, Chevalier, Stéphan, Bougnoux, Philippe, Le Guennec, Jean-Yves, Besson, Pierre, Roger, Sébastien
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Short Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295566/
https://ncbi.nlm.nih.gov/pubmed/25496128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-264
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