Ranolazine inhibits Na(V)1.5-mediated breast cancer cell invasiveness and lung colonization

BACKGROUND: Na(V)1.5 voltage-gated sodium channels are abnormally expressed in breast tumours and their expression level is associated with metastatic occurrence and patients’ death. In breast cancer cells, Na(V)1.5 activity promotes the proteolytic degradation of the extracellular matrix and enhanc...

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Dades bibliogràfiques
Publicat a:Mol Cancer
Autors principals: Driffort, Virginie, Gillet, Ludovic, Bon, Emeline, Marionneau-Lambot, Séverine, Oullier, Thibauld, Joulin, Virginie, Collin, Christine, Pagès, Jean-Christophe, Jourdan, Marie-Lise, Chevalier, Stéphan, Bougnoux, Philippe, Le Guennec, Jean-Yves, Besson, Pierre, Roger, Sébastien
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Short Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295566/
https://ncbi.nlm.nih.gov/pubmed/25496128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-264
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