Ranolazine inhibits Na(V)1.5-mediated breast cancer cell invasiveness and lung colonization

BACKGROUND: Na(V)1.5 voltage-gated sodium channels are abnormally expressed in breast tumours and their expression level is associated with metastatic occurrence and patients’ death. In breast cancer cells, Na(V)1.5 activity promotes the proteolytic degradation of the extracellular matrix and enhanc...

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Foilsithe in:Mol Cancer
Main Authors: Driffort, Virginie, Gillet, Ludovic, Bon, Emeline, Marionneau-Lambot, Séverine, Oullier, Thibauld, Joulin, Virginie, Collin, Christine, Pagès, Jean-Christophe, Jourdan, Marie-Lise, Chevalier, Stéphan, Bougnoux, Philippe, Le Guennec, Jean-Yves, Besson, Pierre, Roger, Sébastien
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2014
Ábhair:
Short Communication
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295566/
https://ncbi.nlm.nih.gov/pubmed/25496128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-264
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