Structural Features of Membrane-bound Glucocerebrosidase and α-Synuclein Probed by Neutron Reflectometry and Fluorescence Spectroscopy

Mutations in glucocerebrosidase (GCase), the enzyme deficient in Gaucher disease, are a common genetic risk factor for the development of Parkinson disease and related disorders, implicating the role of this lysosomal hydrolase in the disease etiology. A specific physical interaction exists between...

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Udgivet i:J Biol Chem
Main Authors: Yap, Thai Leong, Jiang, Zhiping, Heinrich, Frank, Gruschus, James M., Pfefferkorn, Candace M., Barros, Marilia, Curtis, Joseph E., Sidransky, Ellen, Lee, Jennifer C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4295019/
https://ncbi.nlm.nih.gov/pubmed/25429104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.610584
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