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Depth of α-Synuclein in a Bilayer Determined by Fluorescence, Neutron Reflectometry, and Computation
α-Synuclein (α-syn) membrane interactions are implicated in the pathogenesis of Parkinson's disease. Fluorescence and neutron reflectometry (NR) measurements reveal that α-syn penetrates ∼9–14 Å into the outer leaflet of the bilayer, with a substantial portion of the membrane-bound polypeptide...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3274814/ https://ncbi.nlm.nih.gov/pubmed/22325285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.12.051 |
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