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Issues in interpreting the in vivo activity of Aurora-A inhibitors
INTRODUCTION: Based on its role as a mitotic regulatory kinase, overexpressed and associated with aneuploidy in cancer, small molecule inhibitors have been developed for Aurora-A (AURKA) kinase. In preclinical and clinical assessments, these agents have shown efficacy in inducing stable disease or t...
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| Veröffentlicht in: | Expert Opin Ther Targets |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4294965/ https://ncbi.nlm.nih.gov/pubmed/25384454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/14728222.2014.981154 |
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