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Sustained signalling by PTH modulates IP(3) accumulation and IP(3) receptors through cyclic AMP junctions

Parathyroid hormone (PTH) stimulates adenylyl cyclase through type 1 PTH receptors (PTH(1)R) and potentiates the Ca(2+) signals evoked by carbachol, which stimulates formation of inositol 1,4,5-trisphosphate (IP(3)). We confirmed that in HEK cells expressing PTH(1)R, acute stimulation with PTH(1-34)...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Cell Sci
Prif Awduron: Meena, Abha, Tovey, Stephen C., Taylor, Colin W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Company of Biologists 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294780/
https://ncbi.nlm.nih.gov/pubmed/25431134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.163071
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