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Rheb Protein Binds CAD (Carbamoyl-phosphate Synthetase 2, Aspartate Transcarbamoylase, and Dihydroorotase) Protein in a GTP- and Effector Domain-dependent Manner and Influences Its Cellular Localization and Carbamoyl-phosphate Synthetase (CPSase) Activity

Rheb small GTPases, which consist of Rheb1 and Rheb2 (also known as RhebL1) in mammalian cells, are unique members of the Ras superfamily and play central roles in regulating protein synthesis and cell growth by activating mTOR. To gain further insight into the function of Rheb, we carried out a sea...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Sato, Tatsuhiro, Akasu, Hitomi, Shimono, Wataru, Matsu, Chisa, Fujiwara, Yuki, Shibagaki, Yoshio, Heard, Jeffrey J., Tamanoi, Fuyuhiko, Hattori, Seisuke
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294477/
https://ncbi.nlm.nih.gov/pubmed/25422319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.592402
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