Rheb Protein Binds CAD (Carbamoyl-phosphate Synthetase 2, Aspartate Transcarbamoylase, and Dihydroorotase) Protein in a GTP- and Effector Domain-dependent Manner and Influences Its Cellular Localization and Carbamoyl-phosphate Synthetase (CPSase) Activity

Rheb small GTPases, which consist of Rheb1 and Rheb2 (also known as RhebL1) in mammalian cells, are unique members of the Ras superfamily and play central roles in regulating protein synthesis and cell growth by activating mTOR. To gain further insight into the function of Rheb, we carried out a sea...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Sato, Tatsuhiro, Akasu, Hitomi, Shimono, Wataru, Matsu, Chisa, Fujiwara, Yuki, Shibagaki, Yoshio, Heard, Jeffrey J., Tamanoi, Fuyuhiko, Hattori, Seisuke
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294477/
https://ncbi.nlm.nih.gov/pubmed/25422319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.592402
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