Rheb Protein Binds CAD (Carbamoyl-phosphate Synthetase 2, Aspartate Transcarbamoylase, and Dihydroorotase) Protein in a GTP- and Effector Domain-dependent Manner and Influences Its Cellular Localization and Carbamoyl-phosphate Synthetase (CPSase) Activity

Rheb small GTPases, which consist of Rheb1 and Rheb2 (also known as RhebL1) in mammalian cells, are unique members of the Ras superfamily and play central roles in regulating protein synthesis and cell growth by activating mTOR. To gain further insight into the function of Rheb, we carried out a sea...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Sato, Tatsuhiro, Akasu, Hitomi, Shimono, Wataru, Matsu, Chisa, Fujiwara, Yuki, Shibagaki, Yoshio, Heard, Jeffrey J., Tamanoi, Fuyuhiko, Hattori, Seisuke
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294477/
https://ncbi.nlm.nih.gov/pubmed/25422319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.592402
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