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Rheb Protein Binds CAD (Carbamoyl-phosphate Synthetase 2, Aspartate Transcarbamoylase, and Dihydroorotase) Protein in a GTP- and Effector Domain-dependent Manner and Influences Its Cellular Localization and Carbamoyl-phosphate Synthetase (CPSase) Activity

Rheb small GTPases, which consist of Rheb1 and Rheb2 (also known as RhebL1) in mammalian cells, are unique members of the Ras superfamily and play central roles in regulating protein synthesis and cell growth by activating mTOR. To gain further insight into the function of Rheb, we carried out a sea...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Sato, Tatsuhiro, Akasu, Hitomi, Shimono, Wataru, Matsu, Chisa, Fujiwara, Yuki, Shibagaki, Yoshio, Heard, Jeffrey J., Tamanoi, Fuyuhiko, Hattori, Seisuke
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294477/
https://ncbi.nlm.nih.gov/pubmed/25422319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.592402
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