Noxa upregulation by oncogenic activation of MEK/ERK through CREB promotes autophagy in human melanoma cells

Reduction in the expression of the anti-survival BH3-only proteins PUMA and Bim is associated with the pathogenesis of melanoma. However, we have found that the expression of the other BH3-only protein Noxa is commonly upregulated in melanoma cells, and that this is driven by oncogenic activation of...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Liu, Yi Lun, Lai, Fritz, Wilmott, James S., Yan, Xu Guang, Liu, Xiao Ying, Luan, Qi, Guo, Su Tang, Jiang, Chen Chen, Tseng, Hsin-Yi, Scolyer, Richard A., Jin, Lei, Zhang, Xu Dong
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294377/
https://ncbi.nlm.nih.gov/pubmed/25365078
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