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HMGB1-mediated autophagy modulates sensitivity of colorectal cancer cells to oxaliplatin via MEK/ERK signaling pathway

In the present study, we examined the mechanisms of oxaliplatin-induced drug resistance in human colorectal cancer cell lines HT29 and HCT116. Our results demonstrate a significant autophagy expression in CRC cells after an oxaliplatin treatment. Administration of oxaliplatin to human CRC cells sign...

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Detalhes bibliográficos
Publicado no:Cancer Biol Ther
Main Authors: Liu, Weijun, Zhang, Zhenyong, Zhang, Yongxue, Chen, Xinju, Guo, Shikui, Lei, Yi, Xu, Yu, Ji, Chao, Bi, Zhigang, Wang, Kunhua
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622507/
https://ncbi.nlm.nih.gov/pubmed/25778491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1017691
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