INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas

Inositol polyphosphate 4-phosphatase type II (INPP4B) negatively regulates PI3K/Akt signalling and has a tumour suppressive role in some types of cancers. However, we have found that it is upregulated in a subset of melanomas. Here we report that INPP4B can function as an oncogenic driver through ac...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Chi, Meng Na, Guo, Su Tang, Wilmott, James S., Guo, Xiang Yun, Yan, Xu Guang, Wang, Chun Yan, Liu, Xiao Ying, Jin, Lei, Tseng, Hsin-Yi, Liu, Tao, Croft, Amanda, Hondermarck, Hubert, Scolyer, Richard A., Jiang, Chen Chen, Zhang, Xu Dong
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741868/
https://ncbi.nlm.nih.gov/pubmed/26573229
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