Dual MMP7-Proximity-Activated and Folate Receptor-Targeted Nanoparticles for siRNA Delivery

[Image: see text] A dual-targeted siRNA nanocarrier has been synthesized and validated that is selectively activated in environments where there is colocalization of two breast cancer hallmarks, elevated matrix metalloproteinase (MMP) activity and folate receptor overexpression. This siRNA nanocarri...

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Bibliografiske detaljer
Udgivet i:Biomacromolecules
Main Authors: Li, Hongmei, Miteva, Martina, Kirkbride, Kellye C., Cheng, Ming J., Nelson, Christopher E., Simpson, Elaine M., Gupta, Mukesh K., Duvall, Craig L., Giorgio, Todd D.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294138/
https://ncbi.nlm.nih.gov/pubmed/25414930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm501394m
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