Methods and software tools for design evaluation in population pharmacokinetics–pharmacodynamics studies

Population pharmacokinetic (PK)–pharmacodynamic (PKPD) models are increasingly used in drug development and in academic research; hence, designing efficient studies is an important task. Following the first theoretical work on optimal design for nonlinear mixed-effects models, this research theme ha...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Clin Pharmacol
Hauptverfasser: Nyberg, Joakim, Bazzoli, Caroline, Ogungbenro, Kay, Aliev, Alexander, Leonov, Sergei, Duffull, Stephen, Hooker, Andrew C, Mentré, France
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2015
Schlagworte:
Methods in Clinical Pharmacology Review Series
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294071/
https://ncbi.nlm.nih.gov/pubmed/24548174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12352
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