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Influence of the Size of Cohorts in Adaptive Design for Nonlinear Mixed Effects Models: An Evaluation by Simulation for a Pharmacokinetic and Pharmacodynamic Model for a Biomarker in Oncology
PURPOSE: In this study we aimed to evaluate adaptive designs (ADs) by clinical trial simulation for a pharmacokinetic-pharmacodynamic model in oncology and to compare them with one-stage designs, i.e. when no adaptation is performed, using wrong prior parameters. METHODS: We evaluated two one-stage...
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| Publicado no: | Pharm Res |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Kluwer Academic/Plenum Publishers
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5385211/ https://ncbi.nlm.nih.gov/pubmed/26123680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-015-1693-3 |
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