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Pharmacokinetic similarity of biologics: analysis using nonlinear mixed-effects modeling
Our objective was to show with two examples that a pharmacokinetic (PK) similarity analysis can be performed with nonlinear mixed effects models (NLMEM). We used two studies comparing different biosimilars: a three-way crossover trial on somatropin and a parallel group trial on epoetin alpha. For bo...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3400548/ https://ncbi.nlm.nih.gov/pubmed/22205196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2011.216 |
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