Analgesic tolerance to morphine is regulated by PPARγ

BACKGROUND AND PURPOSE: Opioid drugs are potent analgesics. However, their chronic use leads to the rapid development of tolerance to their analgesic effects and subsequent increase of significant side effects, including drug dependence and addiction. Here, we investigated the role of PPARγ in the d...

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Publicat a:Br J Pharmacol
Autors principals: de Guglielmo, Giordano, Kallupi, Marsida, Scuppa, Giulia, Stopponi, Serena, Demopulos, Gregory, Gaitanaris, George, Ciccocioppo, Roberto
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2014
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294048/
https://ncbi.nlm.nih.gov/pubmed/25048682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12851
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