Analgesic tolerance to morphine is regulated by PPARγ

BACKGROUND AND PURPOSE: Opioid drugs are potent analgesics. However, their chronic use leads to the rapid development of tolerance to their analgesic effects and subsequent increase of significant side effects, including drug dependence and addiction. Here, we investigated the role of PPARγ in the d...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Br J Pharmacol
Prif Awduron: de Guglielmo, Giordano, Kallupi, Marsida, Scuppa, Giulia, Stopponi, Serena, Demopulos, Gregory, Gaitanaris, George, Ciccocioppo, Roberto
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BlackWell Publishing Ltd 2014
Pynciau:
Research Papers
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294048/
https://ncbi.nlm.nih.gov/pubmed/25048682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12851
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