Analgesic tolerance to morphine is regulated by PPARγ

BACKGROUND AND PURPOSE: Opioid drugs are potent analgesics. However, their chronic use leads to the rapid development of tolerance to their analgesic effects and subsequent increase of significant side effects, including drug dependence and addiction. Here, we investigated the role of PPARγ in the d...

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Библиографические подробности
Опубликовано в: :Br J Pharmacol
Главные авторы: de Guglielmo, Giordano, Kallupi, Marsida, Scuppa, Giulia, Stopponi, Serena, Demopulos, Gregory, Gaitanaris, George, Ciccocioppo, Roberto
Формат: Artigo
Язык:Inglês
Опубликовано: BlackWell Publishing Ltd 2014
Предметы:
Research Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294048/
https://ncbi.nlm.nih.gov/pubmed/25048682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12851
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