Analgesic tolerance to morphine is regulated by PPARγ

BACKGROUND AND PURPOSE: Opioid drugs are potent analgesics. However, their chronic use leads to the rapid development of tolerance to their analgesic effects and subsequent increase of significant side effects, including drug dependence and addiction. Here, we investigated the role of PPARγ in the d...

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Detalles Bibliográficos
Publicado en:Br J Pharmacol
Autores principales: de Guglielmo, Giordano, Kallupi, Marsida, Scuppa, Giulia, Stopponi, Serena, Demopulos, Gregory, Gaitanaris, George, Ciccocioppo, Roberto
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2014
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294048/
https://ncbi.nlm.nih.gov/pubmed/25048682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12851
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