Pharmacological Inhibition and Genetic Knockdown of Exchange Protein Directly Activated by cAMP 1 Reduce Pancreatic Cancer Metastasis In Vivo

cAMP plays a critical role in regulating migration of various cancers. This role is context dependent and is determined by which of the two main cAMP sensors is at play: cAMP-dependent protein kinase or exchange protein directly activated by cAMP (EPAC). Recently, we have shown that the cAMP sensor...

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Pubblicato in:Mol Pharmacol
Autori principali: Almahariq, Muayad, Chao, Celia, Mei, Fang C., Hellmich, Mark R., Patrikeev, Igor, Motamedi, Massoud, Cheng, Xiaodong
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4293446/
https://ncbi.nlm.nih.gov/pubmed/25385424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.095158
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