Effects of naltrexone on neural and subjective response to alcohol in treatment-seeking alcohol dependent patients

RATIONALE: Positively reinforcing properties of alcohol are in part mediated by activation of the ventral striatum (VS). Alcohol-induced release of endogenous opioids is thought to contribute to this response. Preclinical studies show that the opioid antagonist naltrexone (NTX) can block this cascad...

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Bibliographic Details
Published in:Alcohol Clin Exp Res
Main Authors: Spagnolo, Primavera A., Ramchandani, Vijay A., Schwandt, Melanie L., Zhang, Lishu, Blaine, Sara K., Usala, Julie M., Diamond, Kristie A., Phillips, Monte J., George, David T., Momenan, Reza, Heilig, Markus
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4293087/
https://ncbi.nlm.nih.gov/pubmed/25581657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.12581
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