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Cellular signalling of non-synonymous single-nucleotide polymorphisms of the human μ-opioid receptor (OPRM1)

There is significant variability in individual responses to opioid drugs, which is likely to have a significant genetic component. A number of non-synonymous single-nucleotide polymorphisms (SNPs) in the coding regions of the μ-opioid receptor gene (OPRM1) have been postulated to contribute to this...

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Pubblicato in:Br J Pharmacol
Autori principali: Knapman, Alisa, Connor, Mark
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292952/
https://ncbi.nlm.nih.gov/pubmed/24527749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12644
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