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A6V polymorphism of the human μ-opioid receptor decreases signalling of morphine and endogenous opioids in vitro

BACKGROUND AND PURPOSE: Polymorphisms of the μ opioid receptor (MOPr) may contribute to the variation in responses to opioid drugs in clinical and unregulated situations. The A6V variant of MOPr (MOPr-A6V) is present in up to 20% of individuals in some populations, and may be associated with heighte...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Br J Pharmacol
Prif Awduron: Knapman, Alisa, Santiago, Marina, Connor, Mark
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BlackWell Publishing Ltd 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403092/
https://ncbi.nlm.nih.gov/pubmed/25521224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13047
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