Structural and mechanistic insight into Holliday junction dissolution by Topoisomerase IIIα and RMI1

Repair of DNA double-strand breaks via homologous recombination can produce double Holliday junctions (dHJs) that require enzymatic separation. Topoisomerase IIIα (TopIIIα) together with RMI1 disentangles the final hemicatene intermediate obtained once dHJs have converged. How binding of RMI1 to Top...

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Bibliografiset tiedot
Julkaisussa:Nat Struct Mol Biol
Päätekijät: Bocquet, Nicolas, Bizard, Anna H., Abdulrahman, Wassim, Larsen, Nicolai B., Faty, Mahamadou, Cavadini, Simone, Bunker, Richard D., Kowalczykowski, Stephen C., Cejka, Petr, Hickson, Ian D., Thomä, Nicolas H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292918/
https://ncbi.nlm.nih.gov/pubmed/24509834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2775
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