Structural and mechanistic insight into Holliday junction dissolution by Topoisomerase IIIα and RMI1

Repair of DNA double-strand breaks via homologous recombination can produce double Holliday junctions (dHJs) that require enzymatic separation. Topoisomerase IIIα (TopIIIα) together with RMI1 disentangles the final hemicatene intermediate obtained once dHJs have converged. How binding of RMI1 to Top...

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Udgivet i:Nat Struct Mol Biol
Main Authors: Bocquet, Nicolas, Bizard, Anna H., Abdulrahman, Wassim, Larsen, Nicolai B., Faty, Mahamadou, Cavadini, Simone, Bunker, Richard D., Kowalczykowski, Stephen C., Cejka, Petr, Hickson, Ian D., Thomä, Nicolas H.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292918/
https://ncbi.nlm.nih.gov/pubmed/24509834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2775
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