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Structural and mechanistic insight into Holliday junction dissolution by Topoisomerase IIIα and RMI1
Repair of DNA double-strand breaks via homologous recombination can produce double Holliday junctions (dHJs) that require enzymatic separation. Topoisomerase IIIα (TopIIIα) together with RMI1 disentangles the final hemicatene intermediate obtained once dHJs have converged. How binding of RMI1 to Top...
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| Publicado no: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4292918/ https://ncbi.nlm.nih.gov/pubmed/24509834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2775 |
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