A Small Molecule β2 Integrin Agonist Improves Chronic Kidney Allograft Survival by Reducing Leukocyte Recruitment and Accompanying Vasculopathy

Kidney allograft rejection is associated with infiltration of inflammatory CD11b+ leukocytes. A CD11b agonist leukadherin-1 (LA1) increases leukocyte adhesion, preventing their transmigration and tissue recruitment in vivo. Here, we test the extent to which LA1-mediated activation of CD11b/CD18 enha...

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Vydáno v:Front Med (Lausanne)
Hlavní autoři: Khan, Samia Q., Guo, Lingling, Cimbaluk, David J., Elshabrawy, Hatem, Faridi, Mohd Hafeez, Jolly, Meenakshi, George, James F., Agarwal, Anupam, Gupta, Vineet
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2014
Témata:
Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291902/
https://ncbi.nlm.nih.gov/pubmed/25593918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmed.2014.00045
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