Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability

[Image: see text] The kinase/endonuclease inositol requiring enzyme 1 (IRE1α), one of the sensors of unfolded protein accumulation in the endoplasmic reticulum that triggers the unfolded protein response (UPR), has been investigated as an anticancer target. We identified potent allosteric inhibitors...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Harrington, Paul E., Biswas, Kaustav, Malwitz, David, Tasker, Andrew S., Mohr, Christopher, Andrews, Kristin L., Dellamaggiore, Ken, Kendall, Richard, Beckmann, Holger, Jaeckel, Peter, Materna-Reichelt, Silvia, Allen, Jennifer R., Lipford, J. Russell
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291719/
https://ncbi.nlm.nih.gov/pubmed/25589933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500315b
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