Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

Ire1 (Ern1) is an unusual transmembrane protein kinase essential for the endoplasmic reticulum (ER) unfolded protein response (UPR). Activation of Ire1 by association of its N-terminal ER luminal domains promotes autophosphorylation by its cytoplasmic kinase domain, leading to activation of the C-te...

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Detalhes bibliográficos
Main Authors: Ali, Maruf M U, Bagratuni, Tina, Davenport, Emma L, Nowak, Piotr R, Silva-Santisteban, M Cris, Hardcastle, Anthea, McAndrews, Craig, Rowlands, Martin G, Morgan, Gareth J, Aherne, Wynne, Collins, Ian, Davies, Faith E, Pearl, Laurence H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049214/
https://ncbi.nlm.nih.gov/pubmed/21317875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.18
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