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Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response
Ire1 (Ern1) is an unusual transmembrane protein kinase essential for the endoplasmic reticulum (ER) unfolded protein response (UPR). Activation of Ire1 by association of its N-terminal ER luminal domains promotes autophosphorylation by its cytoplasmic kinase domain, leading to activation of the C-te...
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| 主要な著者: | , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3049214/ https://ncbi.nlm.nih.gov/pubmed/21317875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.18 |
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