Cytomegalovirus Downregulates IRE1 to Repress the Unfolded Protein Response

During viral infection, a massive demand for viral glycoproteins can overwhelm the capacity of the protein folding and quality control machinery, leading to an accumulation of unfolded proteins in the endoplasmic reticulum (ER). To restore ER homeostasis, cells initiate the unfolded protein response...

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Main Authors: Stahl, Sebastian, Burkhart, Julia M., Hinte, Florian, Tirosh, Boaz, Mohr, Hermine, Zahedi, René P., Sickmann, Albert, Ruzsics, Zsolt, Budt, Matthias, Brune, Wolfram
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2013
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738497/
https://ncbi.nlm.nih.gov/pubmed/23950715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003544
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