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Cytomegalovirus Downregulates IRE1 to Repress the Unfolded Protein Response
During viral infection, a massive demand for viral glycoproteins can overwhelm the capacity of the protein folding and quality control machinery, leading to an accumulation of unfolded proteins in the endoplasmic reticulum (ER). To restore ER homeostasis, cells initiate the unfolded protein response...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3738497/ https://ncbi.nlm.nih.gov/pubmed/23950715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003544 |
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