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Pyrimidine-Based Tricyclic Molecules as Potent and Orally Efficacious Inhibitors of Wee1 Kinase

[Image: see text] Aided by molecular modeling, compounds with a pyrimidine-based tricyclic scaffold were designed and confirmed to inhibit Wee1 kinase. Structure–activity studies identified key pharmacophores at the aminoaryl and halo-benzene regions responsible for binding affinity with sub-nM K(i)...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Tong, Yunsong, Torrent, Maricel, Florjancic, Alan S., Bromberg, Kenneth D., Buchanan, Fritz G., Ferguson, Debra C., Johnson, Eric F., Lasko, Loren M., Maag, David, Merta, Philip J., Olson, Amanda M., Osterling, Donald J., Soni, Nirupama, Shoemaker, Alexander R., Penning, Thomas D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2014
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291713/
https://ncbi.nlm.nih.gov/pubmed/25589931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5002745
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