Pyrimidine-Based Tricyclic Molecules as Potent and Orally Efficacious Inhibitors of Wee1 Kinase

[Image: see text] Aided by molecular modeling, compounds with a pyrimidine-based tricyclic scaffold were designed and confirmed to inhibit Wee1 kinase. Structure–activity studies identified key pharmacophores at the aminoaryl and halo-benzene regions responsible for binding affinity with sub-nM K(i)...

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發表在:ACS Med Chem Lett
Main Authors: Tong, Yunsong, Torrent, Maricel, Florjancic, Alan S., Bromberg, Kenneth D., Buchanan, Fritz G., Ferguson, Debra C., Johnson, Eric F., Lasko, Loren M., Maag, David, Merta, Philip J., Olson, Amanda M., Osterling, Donald J., Soni, Nirupama, Shoemaker, Alexander R., Penning, Thomas D.
格式: Artigo
語言:Inglês
出版: American Chemical Society 2014
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291713/
https://ncbi.nlm.nih.gov/pubmed/25589931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5002745
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