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Pyrimidine-Based Tricyclic Molecules as Potent and Orally Efficacious Inhibitors of Wee1 Kinase
[Image: see text] Aided by molecular modeling, compounds with a pyrimidine-based tricyclic scaffold were designed and confirmed to inhibit Wee1 kinase. Structure–activity studies identified key pharmacophores at the aminoaryl and halo-benzene regions responsible for binding affinity with sub-nM K(i)...
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Pubblicato in: | ACS Med Chem Lett |
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Autori principali: | , , , , , , , , , , , , , , |
Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
American Chemical
Society
2014
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Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4291713/ https://ncbi.nlm.nih.gov/pubmed/25589931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5002745 |
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