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Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195
[Image: see text] To investigate the role played by the unique pre-DFG residue Val 195 of Cdc7 kinase on the potency of azaindole-chloropyridines (1), a series of novel analogues with various chloro replacements were synthesized and evaluated for their inhibitory activity against Cdc7. X-ray cocryst...
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Main Authors: | , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American
Chemical Society
2013
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027468/ https://ncbi.nlm.nih.gov/pubmed/24900653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300348c |
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