Pyrimidine-Based Tricyclic Molecules as Potent and Orally Efficacious Inhibitors of Wee1 Kinase

[Image: see text] Aided by molecular modeling, compounds with a pyrimidine-based tricyclic scaffold were designed and confirmed to inhibit Wee1 kinase. Structure–activity studies identified key pharmacophores at the aminoaryl and halo-benzene regions responsible for binding affinity with sub-nM K(i)...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:ACS Med Chem Lett
Auteurs principaux: Tong, Yunsong, Torrent, Maricel, Florjancic, Alan S., Bromberg, Kenneth D., Buchanan, Fritz G., Ferguson, Debra C., Johnson, Eric F., Lasko, Loren M., Maag, David, Merta, Philip J., Olson, Amanda M., Osterling, Donald J., Soni, Nirupama, Shoemaker, Alexander R., Penning, Thomas D.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2014
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291713/
https://ncbi.nlm.nih.gov/pubmed/25589931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5002745
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires