Pyrimidine-Based Tricyclic Molecules as Potent and Orally Efficacious Inhibitors of Wee1 Kinase

[Image: see text] Aided by molecular modeling, compounds with a pyrimidine-based tricyclic scaffold were designed and confirmed to inhibit Wee1 kinase. Structure–activity studies identified key pharmacophores at the aminoaryl and halo-benzene regions responsible for binding affinity with sub-nM K(i)...

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Publicado en:ACS Med Chem Lett
Main Authors: Tong, Yunsong, Torrent, Maricel, Florjancic, Alan S., Bromberg, Kenneth D., Buchanan, Fritz G., Ferguson, Debra C., Johnson, Eric F., Lasko, Loren M., Maag, David, Merta, Philip J., Olson, Amanda M., Osterling, Donald J., Soni, Nirupama, Shoemaker, Alexander R., Penning, Thomas D.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2014
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291713/
https://ncbi.nlm.nih.gov/pubmed/25589931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5002745
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