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Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells
The mammalian target of rapamycin complex 1 (mTORC1) integrates multiple signals from growth factors, nutrients, and cellular energy status to control a wide range of metabolic processes, including mRNA biogenesis; protein, nucleotide, and lipid synthesis; and autophagy. Deregulation of the mTORC1 p...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4291663/ https://ncbi.nlm.nih.gov/pubmed/25524627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417015112 |
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