Atovaquone Tolerance in Plasmodium falciparum Parasites Selected for High-Level Resistance to a Dihydroorotate Dehydrogenase Inhibitor

Atovaquone is a component of Malarone, a widely prescribed antimalarial combination, that targets malaria respiration. Here we show that parasites with high-level resistance to an inhibitor of dihydroorotate dehydrogenase demonstrate unexpected atovaquone tolerance. Fortunately, the tolerance is dim...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Guler, Jennifer L., White, John, Phillips, Margaret A., Rathod, Pradipsinh K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291421/
https://ncbi.nlm.nih.gov/pubmed/25331708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02347-14
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