A Chemical Rescue Screen Identifies a Plasmodium falciparum Apicoplast Inhibitor Targeting MEP Isoprenoid Precursor Biosynthesis

The apicoplast is an essential plastid organelle found in Plasmodium parasites which contains several clinically validated antimalarial-drug targets. A chemical rescue screen identified MMV-08138 from the “Malaria Box” library of growth-inhibitory antimalarial compounds as having specific activity a...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Wu, Wesley, Herrera, Zachary, Ebert, Danny, Baska, Katie, Cho, Seok H., DeRisi, Joseph L., Yeh, Ellen
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291372/
https://ncbi.nlm.nih.gov/pubmed/25367906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03342-14
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