A Chemical Rescue Screen Identifies a Plasmodium falciparum Apicoplast Inhibitor Targeting MEP Isoprenoid Precursor Biosynthesis

The apicoplast is an essential plastid organelle found in Plasmodium parasites which contains several clinically validated antimalarial-drug targets. A chemical rescue screen identified MMV-08138 from the “Malaria Box” library of growth-inhibitory antimalarial compounds as having specific activity a...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Wu, Wesley, Herrera, Zachary, Ebert, Danny, Baska, Katie, Cho, Seok H., DeRisi, Joseph L., Yeh, Ellen
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291372/
https://ncbi.nlm.nih.gov/pubmed/25367906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03342-14
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars