Bacterial Resistance to Leucyl-tRNA Synthetase Inhibitor GSK2251052 Develops during Treatment of Complicated Urinary Tract Infections

GSK2251052, a novel leucyl-tRNA synthetase (LeuRS) inhibitor, was in development for the treatment of infections caused by multidrug-resistant Gram-negative pathogens. In a phase II study (study LRS114688) evaluating the efficacy of GSK2251052 in complicated urinary tract infections, resistance deve...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: O'Dwyer, Karen, Spivak, Aaron T., Ingraham, Karen, Min, Sharon, Holmes, David J., Jakielaszek, Charles, Rittenhouse, Stephen, Kwan, Alan L., Livi, George P., Sathe, Ganesh, Thomas, Elizabeth, Van Horn, Stephanie, Miller, Linda A., Twynholm, Monique, Tomayko, John, Dalessandro, Marybeth, Caltabiano, Madelyn, Scangarella-Oman, Nicole E., Brown, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291364/
https://ncbi.nlm.nih.gov/pubmed/25348524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03774-14
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