NRG1, ERBB4 and AKT1 Epistasis Increases Schizophrenia Risk and is Biologically Validated via Functional Neuroimaging in Healthy Controls

CONTEXT: NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis. OBJECTIVE: We sought to examine epistasis between NRG1 and selected NMDA-glutamate pathway partners implic...

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Publicado no:Arch Gen Psychiatry
Main Authors: Nicodemus, Kristin K., Law, Amanda J., Radulescu, Eugenia, Luna, Augustin, Kolachana, Bhaskar, Vakkalanka, Radhakrishna, Rujescu, Dan, Giegling, Ina, Straub, Richard E., McGee, Kate, Gold, Bert, Dean, Michael, Muglia, Pierandrea, Callicott, Joseph H., Tan, Hao-Yang, Weinberger, Daniel R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291187/
https://ncbi.nlm.nih.gov/pubmed/20921115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/archgenpsychiatry.2010.117
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