Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119

BACKGROUND AND PURPOSE: GPR119 is a Gαs-coupled 7TM receptor activated by endogenous lipids such as oleoylethanolamide (OEA) and by the dietary triglyceride metabolite 2-monoacylglycerol. GPR119 stimulates enteroendocrine hormone and insulin secretion. But despite massive drug discovery efforts in t...

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Detaylı Bibliyografya
Yayımlandı:Br J Pharmacol
Asıl Yazarlar: Engelstoft, M S, Norn, C, Hauge, M, Holliday, N D, Elster, L, Lehmann, J, Jones, R M, Frimurer, T M, Schwartz, T W
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BlackWell Publishing Ltd 2014
Konular:
Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4290716/
https://ncbi.nlm.nih.gov/pubmed/25117266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12877
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