Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119

BACKGROUND AND PURPOSE: GPR119 is a Gαs-coupled 7TM receptor activated by endogenous lipids such as oleoylethanolamide (OEA) and by the dietary triglyceride metabolite 2-monoacylglycerol. GPR119 stimulates enteroendocrine hormone and insulin secretion. But despite massive drug discovery efforts in t...

詳細記述

保存先:
書誌詳細
出版年:Br J Pharmacol
主要な著者: Engelstoft, M S, Norn, C, Hauge, M, Holliday, N D, Elster, L, Lehmann, J, Jones, R M, Frimurer, T M, Schwartz, T W
フォーマット: Artigo
言語:Inglês
出版事項: BlackWell Publishing Ltd 2014
主題:
Research Papers
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4290716/
https://ncbi.nlm.nih.gov/pubmed/25117266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12877
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