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Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors
The tryptophan (TRP) to kynurenine (KYN) metabolic pathway is now firmly established as a key regulator of innate and adaptive immunity. A plethora of preclinical models suggests that this immune tolerance pathway – driven by the key and rate-limiting enzymes indoleamine-2,3-dioxygenase and TRP-2,3-...
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| Publicado no: | Front Immunol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4290671/ https://ncbi.nlm.nih.gov/pubmed/25628622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00673 |
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