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Runx2-Smad signaling impacts the progression of tumor-induced bone disease
Runx2, a master regulator of osteogenesis, is abnormally expressed in advanced prostate cancer. Here we addressed Runx2 contribution to formation of prostate cancer-related osteolytic and osteoblastic bone lesions by mediating TGFβ/BMP signaling through direct interaction with Smads. Further, we exa...
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| Publicado no: | Int J Cancer |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4289427/ https://ncbi.nlm.nih.gov/pubmed/25053011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.29094 |
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