Runx2 Association with Progression of Prostate Cancer in Patients: Mechanisms Mediating Bone Osteolysis and Osteoblastic Metastatic Lesions

Runx2, a bone-specific transcriptional regulator, is abnormally expressed in highly metastatic prostate cancer cells. Here we identified the functional activities of Runx2 in facilitating tumor growth and osteolysis. Our studies demonstrate that negligible Runx2 is found in normal prostate epithelia...

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Detalhes bibliográficos
Main Authors: Akech, Jacqueline, Wixted, John J., Bedard, Krystin, van der Deen, Margaretha, Hussain, Sadiq, Guise, Theresa A., van Wijnen, Andre J., Stein, Janet L., Languino, Lucia R., Altieri, Dario C., Pratap, Jitesh, Keller, Evan, Stein, Gary S., Lian, Jane B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820596/
https://ncbi.nlm.nih.gov/pubmed/19915614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.389
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